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Xanax dosage for general anxiety disorder What is the most effective antidepressant for bipolar disorder? Depression affects approximately 8% to 20% of individuals diagnosed with bipolar disorder. In these individuals, antidepressants may be effective. But they can dangerous for this group. Patients with bipolar disorder may have a different response to antidepressants. For some people, it is important to first try an antidepressant for a full cycle, then switch to a different antidepressant. The most effective antidepressant for bipolar disorder is a serotonin reuptake inhibitor (SSRI) or a tricyclic antidepressant, such as citalopram. These medications decrease serotonin's level of activity, which may decrease mania while it increases depression in other cases. However, many people have different responses when switching between antidepressants. For example, some individuals might need an antidepressant that is slightly less "active" to control their symptoms. Some people may be better off with an antidepressant that is more potent. For example, some people can tolerate stronger antidepressants than the one that is working for them. The choice of antidepressant for a particular individual depends in part on the severity of symptoms. Some patients with bipolar disorder do better a milder antidepressant, while others have trouble tolerating it. Sometimes it is helpful to take an SSRI with a tricyclic antidepressant. Other times, switching antidepressants is useful while an antidepressant being prescribed. Who is the best antidepressant to start with in bipolar disorder? If you currently take an active antidepressant, and you have never experienced significant improvement in your symptoms, and you are taking no risk factors for suicide, your symptoms may improve if you switch antidepressants. If you have tried other antidepressants, such as an SSRI or tricyclic antidepressants, with little success, then you may try an active antidepressant, even if you have only a milder depressive episode. Some people have reported that they were able to significantly improve depression symptoms with antidepressants that had been prescribed for them before. The most common reason that an individual switches antidepressant is to increase their mood, cope with stressful situations, or to treat a mood disorder that is not responsive to an antidepressant. Why does an antidepressant work on bipolar depression? Most antidepressants work by changing the levels of certain neurotransmitters in the brain. One neurotransmitter, serotonin, is thought to play a role in many symptoms of depression – such as low energy, trouble concentrating, and motivation. Serotonin seems to play an important role in bipolar disorder. Serotonin does not work in a vacuum. When it is released in higher amounts from the presynaptic neuron, serotonin acts on various targets within the CNS. Antidepressants inhibit actions of these targets that increase serotonin. This means that antidepressants reduce the number of neurotransmitters that are released through presynaptic neurons, and that these drugs decrease the amount of serotonin that is available for release by the neurons themselves. This results in lowered levels of serotonin the brain, as well decreased levels of depression symptoms. This change in neurotransmitter levels may result symptoms that are similar to those of mood symptoms seen in disorders. For example, someone who is taking an SSRI may have less energy, concentration, and fewer or symptoms of depression. In addition to serotonin, other online pharmacy oxycodone 30 mg with prescription neurotransmitters play roles in mood and symptoms. Antidepressants may act by increasing the levels of noradrenaline and adrenaline in the brain. Serotonin also can increase the levels of glutamate, norepinephrine, and dopamine. Antidepressants that have been tested in research do not seem to affect serotonin level levels. For example, fluoxetine is used off-label to treat depression in patients diagnosed with obsessive compulsive disorder (OCD). However, fluoxetine has had limited success in treating these symptoms depressed patients. In contrast to antidepressants that increase serotonin levels, other medications, such as serotonin reuptake inhibitors (SSRI) can increase serotonin levels. Some experts have suggested that the SSRI may be useful for people who have not responded to antidepressant medications. However, it is important to remember that the SSRI has some side effects. When considering taking an SSRI, it is important to talk with your healthcare provider to make sure that you are taking a safe and effective medication.
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